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Buy Methotrexate tablets online

How and where to order Methotrexate 2.5, 5, 7.5, 10, 15, 25 mg tablets online:

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Forms:2.5 mg, 5 mg, 7.5 mg, 10 mg, 15 mg, 25 mg tablets
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Type:Methotrexate brand, Rheumatrex generic
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Indications and usage:

Methotrexate tablets are a diydrofolate reductase inhibitor indicated for the treatment of:

  • adults and pediatric patients with acute lymphoblastic leukemia as part of a combination chemotherapy maintenance regimen
  • adults with mycosis fungoides
  • adults with relapsed or refractory non-Hodgkin lymphoma as part of a metronomic combination regimen
  • adults with rheumatoid arthritis
  • pediatric patients with polyarticular juvenile idiopathic arthritis
  • adults with severe psoriasis

    This medication is also used to treat breast cancer, various neoplastic diseases, autoimmune diseases, ectopic pregnancy, and other medical conditions.


    Contraindications:

  • in pregnancy for non-neoplastic diseases
  • history of severe hypersensitivity to methotrexate


    Dosage forms and strengths:

    Methotrexate 2.5 mg, 5 mg, 7.5 mg, 10 mg, 15 mg, 25 mg tablets for oral administration.


    Dosage and administration:

  • Instruct patients and caregivers to take the recommended dosage as directed, because medication errors have led to deaths.
  • Verify pregnancy status in females of reproductive potential before starting methotrexate tablets.
  • Acute lymphoblastic leukemia: the recommended dosage is 20 mg/m2 orally once weekly as a part of a combination chemotherapy maintenance regimen.
  • Mycosis fungoides: the recommended dosage is 25 to 75 mg orally once weekly as monotherapy; 10 mg/m2 orally twice weekly as part of combination chemotherapy.
  • Relapsed or refractory non-Hodgkin lymphoma: the recommended dosage is 2.5 mg orally two to four times per week as part of metronomic combination chemotherapy.
  • Rheumatoid arthritis: the recommended starting dosage is 7.5 mg orally once weekly; adjust dose to achieve an optimal response.
  • Polyarticular juvenile idiopathic arthritis: the recommended starting dosage is 10 mg/m2 orally once weekly; adjust dose to achieve an optimal response.
  • Psoriasis: the recommended dosage is 10 to 25 mg orally once weekly until adequate response is achieved.


    Overdosage:

    Signs and symptoms

    Manifestations of methotrexate overdosage include adverse reactions reported at pharmacologic doses, particularly hematologic and gastrointestinal reactions (e.g., thrombocytopenia, leukopenia, anemia, pancytopenia, mucositis, myelosuppression, stomatitis, oral ulceration, vomiting, nausea, gastrointestinal ulceration, gastrointestinal bleeding). In some cases, no symptoms were reported; however, sepsis or septic shock, renal failure, and aplastic anemia were also reported.

    Management

    Leucovorin and levoleucovorin are indicated for diminishing the methotrexate adverse reactions of methotrexate overdosage. Administer leucovorin or levoleucovorin as soon as possible after methotrexate overdosage). Monitor serum creatinine and methotrexate levels to guide leucovorin or levoleucovorin therapy. Refer to the leucovorin or levoleucovorin prescribing information for additional dosage information.

    Glucarpidase is indicated for the treatment of toxic plasma methotrexate concentrations (>1 micromole per liter) in patients with delayed methotrexate clearance due to impaired renal function. Refer to the glucarpidase prescribing information for additional dosage information.

    Administer concomitant hydration and urinary alkalinization.

    Neither hemodialysis nor peritoneal dialysis has been shown to improve methotrexate elimination; however, methotrexate has been effectively cleared with acute, intermittent hemodialysis using a high-flux dialyzer.


    Warnings and precautions:

  • Serious infections: monitor patients for infection during and after treatment with methotrexate tablets. Withhold or discontinue this medication for serious infections as appropriate.
  • Neurotoxicity: monitor patients for neurotoxicity and withhold or discontinue methotrexate pills as appropriate.
  • Secondary malignancies: can occur with methotrexate.
  • Tumor lysis syndrome: institute appropriate prophylactic measures in patients at risk for tumor lysis syndrome prior to initiation of methotrexate tablets.
  • Immunizations and risk live vaccines: immunizations with live vaccines is not recommended. Follow current vaccination practice guidelines.
  • Infertility: can cause impairment of fertility, oligospermia, and menstrual dysfunction.


    Side effects, adverse reactions:

    The most common adverse reactions of methotrexate oral tablets include ulcerative stomatitis, leukopenia, nausea, abdominal distress.

    To report suspected adverse reactions of methotrexate pills contact pharmaceutical company manufactured or distributed this medication or your local FDA.


    Drug interactions:

    Coadministration of methotrexate with the following products may increase methotrexate plasma concentrations, which may increase the risk of methotrexate severe adverse reactions:

  • oral antibiotics (including neomycin)
  • antifolate drugs (e.g., dapsone, pemetrexed, pyrimethamine and sulfonamides)
  • oral or intravenous penicillin or sulfonamide antibiotics
  • aspirin and other nonsteroidal anti-inflammatory drugs
  • highly protein-bound drugs (e.g., oral anticoagulants, phenytoin
  • hepatotoxic products
  • salicylates, sulfonamides, sulfonylureas
  • proton pump inhibitorsand tetracyclines)
  • weak acids (e.g., salicylates)
  • probenecid
  • nephrotoxic products
  • nitrous oxide

    Coadministration of methotrexate with folic acid or its derivatives decreases the clinical effectiveness of methotrexate in patients with neoplastic diseases.


    Usage in specific populations:

    Pregnancy

    Methotrexate tablets are contraindicated in pregnant women with non-neoplastic diseases. Advise pregnant women with neoplastic diseases of the potential risk to a fetus.

    Lactation

    Instruct not to breastfeed.

    Females and males of reproductive potential

    Methotrexate can cause malformations and fetal death at doses less than or equal to the recommended clinical doses.

    Pediatric use

    The safety and effectiveness of methotrexate tablets in pediatric patients have been established for the treatment of acute lymphoblastic leukemia as part of the combination chemotherapy maintenance regimen and the treatment of polyarticular juvenile idiopathic arthritis. The safety and effectiveness of methotrexate pills have not been established in pediatric patients for the other indications.

    Geriatric use

    Clinical studies of methotrexate did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects.

    Renal impairment

    Methotrexate elimination is reduced in patients with renal impairment. Patients with renal impairment are at increased risk for methotrexate adverse reactions. Closely monitor patients with renal impairment [creatinine clearance (CLcr) less than 90 mL/min, Cockcroft-Gault] for adverse reactions. Reduce the dosage or discontinue methotrexate tablets as appropriate.

    Hepatic impairment

    The pharmacokinetics and safety of methotrexate in patients with hepatic impairment is unknown. Patients with hepatic impairment may be at increased risk for methotrexate adverse reactions based on the elimination characteristics of methotrexate. Closely monitor patients with hepatic impairment for adverse reactions. Reduce the dosage or discontinue this drug as appropriate.


    Where to buy methotrexate online:

    To purchase Methotrexate 2.5 mg, 5 mg, 7.5 mg, 10 mg, 15 mg, 25 mg tablets from reliable online pharmacies and drugstores at low prices please use resources described above on this webpage.


    Here is a list of popular medications containing methotrexate as a main active pharmaceutical ingredient; their trade names, forms, doses, companies - manufacturers, distributors, suppliers, researchers and developers:

    Trade name of the drug Pharmaceutical forms and doses Companies
    Folitrax
  • Injectable; Injection; Methotrexate 7.5 mg / ml, 15 mg / ml
  • Tablets; Oral; Methotrexate 2.5 mg, 5 mg, 7.5 mg, 10 mg, 15 mg, 25 mg
    		•
  • Ipca Laboratories
    		•
    Imutrex
  • Injectable; Injection; Methotrexate 15 mg / ml
  • Tablets; Oral; Methotrexate 2.5 mg, 5 mg, 7.5 mg, 10 mg
    		•
  • Cipla
    		•
    Leetrexate
  • Tablets; Oral; Methotrexate 2.5 mg, 5 mg, 7.5 mg, 10 mg, 15 mg
    		•
  • JohnLee Pharmaceuticals
    		•
    Methocel
  • Injectable; Injection; Methotrexate 15 mg / ml
  • Tablets; Oral; Methotrexate 2.5 mg
    		•
  • Celon Laboratories
    		•
    Rheumatrex
  • Tablets; Oral; Methotrexate 2.5 mg, 10 mg
    		•
  • Wyeth
  • Stada
    		•


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